1. Involvement of the Penta-EF-Hand Protein Pef1p in the Ca2+- ... - PLOS
Arrows indicate the critical calcium interacting residues E180, E181, and E248. ... Transition of Sar1p from the GTP-bound to the GDP-bound state was monitored by ...
Although it is well established that the coat protein complex II (COPII) mediates the transport of proteins and lipids from the endoplasmic reticulum (ER) to the Golgi apparatus, the regulation of the vesicular transport event and the mechanisms that act to counterbalance the vesicle flow between the ER and Golgi are poorly understood. In this study, we present data indicating that the penta-EF-hand Ca2+-binding protein Pef1p directly interacts with the COPII coat subunit Sec31p and regulates COPII assembly in Saccharomyces cerevisiae. ALG-2, a mammalian hom*olog of Pef1p, has been shown to interact with Sec31A in a Ca2+-dependent manner and to have a role in stabilizing the association of the Sec13/31 complex with the membrane. However, Pef1p displayed reversed Ca2+ dependence for Sec13/31p association; only the Ca2+-free form of Pef1p bound to the Sec13/31p complex. In addition, the influence on COPII coat assembly also appeared to be reversed; Pef1p binding acted as a kinetic inhibitor to delay Sec13/31p recruitment. Our results provide further evidence for a linkage between Ca2+-dependent signaling and ER-to-Golgi trafficking, but its mechanism of action in yeast seems to be different from the mechanism reported for its mammalian hom*olog ALG-2.
2. Gross Domestic Product | U.S. Bureau of Economic Analysis (BEA)
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3. [PDF] Master Builders Australia Submission to the Senate Education and ...
Feb 5, 2021 · Represents about 11% of GDP, the second largest sector within the economy;. ▫. Trains more than one third of the total number of trades-based ...
4. Egypt attracts foreign investment as currency falls - Financial Times
Mar 22, 2017 · Egypt is grappling with a budget deficit that reached 12.2 per cent of gross domestic product ... Domestic debt is high at 95 per cent of GDP. The ...
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5. 2018 GDP figure revised down to 0.9% - Politics - Ansa.it
Mar 1, 2019 · ISTAT said Friday that Italy's gross domestic product rose by 0.9% in 2018 after revised down its provisional estimate of 1% growth last ...
ISTAT said Friday that Italy's gross domestic product rose by 0.9% in 2018 after revised down its provisional estimate of 1% growth last year. The government put Italy's growth rate for 2018 at 1% in its forecasts late in December. (ANSA)
6. gdp e248 | Discover - Kwai
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7. Ectopic expression of eIF2Bε in rat skeletal muscle rescues the sepsis ...
2010 Aug; 299(2): E241–E248. Published online 2010 May 18. doi: 10.1152 ... The rate of exchange of [3H]GDP for unlabeled GDP was calculated as the ...
Eukaryotic initiation factor 2B (eIF2B) is a guanine nucleotide exchange factor (GEF) whose activity is both tightly regulated and rate-controlling with regard to global rates of protein synthesis. Skeletal muscle eIF2B activity and expression of its ...
8. UAE bankruptcy no longer leads straight to prison - Financial Times
Mar 22, 2017 · The government's ambition is to boost the contribution of SMEs to GDP from 40 per cent now to 45 per cent in 2021. It hopes to foster 40,000 ...
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9. [PDF] Egypt's IMF Program: Assessing the Political Economy Challenges
content/083a15cc-e248-11e6-9645-c9357a75844a. 14 IMF ... 53 Mohamed Hamama, “Sisi Says Military Economy is 1.5% of Egypt's GDP, But How Accurate Is This?
10. A Rational Economic Model of Paygo Tax Rates
... GDP, real wages and the real return to capital since 1950. With uniform risk ... e248-4dc9-aac8-f, Tilburg University, School of Economics and ...
We argue that paygo rates are determined by a representative agent and a benevolent government jointly maximizing the expected life-time utility of the agent. The distributions of labor and capital in
11. [PDF] NBAA President Ed Bolen Testimony, House TI Hearing, FAA ...
Feb 7, 2023 · gross domestic product. Considering the vast challenges facing ... 64(4):e245-e248. 11. Page 12. aiding employers in understanding the ...
12. Splitting the functions of Rim2, a mitochondrial iron/pyrimidine carrier
Jan 18, 2019 · Potential proton coupler E248, and contact residue K299 are indicated in red and blue respectively. ... GDP exchanger, which may also have some ...
Rim2 is an unusual mitochondrial carrier protein capable of transporting both iron and pyrimidine nucleotides. Here we characterize two point mutations generated in the predicted substrate-binding site, finding that they yield disparate effects on iron ...